The vehicle, which was northbound on South End Avenue, crashed around 1 a.m. near Two World Financial Center.
According to the New York City Police Department, Lena Pitu, 76, of Queens, was driving when the cab hit a metal barrier on the west sidewalk near Liberty Street.
No other cars were involved. No one was hurt.
Police found Pitu still inside when they responded.
It appears she had a medical episode, causing her to lose control of her cab. She did not have a passenger in the car at the time.
She was taken to Bellevue Hospital where she was pronounced dead.
The investigation is ongoing.