They reportedly grabbed cash that was on a piece of furniture in the living room.
But police say the homeowner, who is a licensed pistol permit holder, produced a handgun and chased after the suspects, firing one shot. It was unknown if either of the suspects was hit.
The victim described one of the suspects as a black man, approximately 5-foot-6, 200 pounds, wearing a black puffy jacket and a dark skullcap. There was no description of the second suspect.
The man, who was uninjured, was home alone at the time of the attack, according to officials. He said he was shaken when he returned home after being interviewed by police.