The driver of the van is dead. Authorities believe he may have had a heart attack while driving.
"It came from nowhere," one witness said. "I didn't even see where it came from."
The incident happened at East 125th Street and Lexington Avenue, at the entrance to the Nos. 4, 5 and 6 lines.
"People was bleeding from their head, people was bleeding from their back," the witness said.
No subway delays were reported as a result of the crash.