That return gave New York a 30-3 lead less than a minute into the second quarter, one that second- and third-stringers barely managed to maintain.
Hixon, starting at wide receiver because Plaxico Burress, Amani Toomer and Steve Smith didn't suit up, caught 11- and 24-yard touchdown passes from Manning in the first quarter. He returned a free kick 82 yards for a touchdown after a series of Cleveland mistakes that included a safety on a punt by Dave Zastudil that he kicked into one of his teammates.
After Phil Dawson's 56-yard field goal on their first drive, the Browns simply self-destructed.
On New York's next series, Eric Wright's 53-yard pass interference penalty for mugging Sinorice Moss set up the Giants' first touchdown.
The next New York series started from the Cleveland 49 because Michael Adams interfered with Hixon's attempt to catch a punt, giving the Giants 15 extra yards. They got 15 more when Andra Davis was called for throwing a punch at a Giant - and missing, which is what the Browns' starters were doing all night.
That drive ended in the second TD pass to Hixon from Manning, who was 4-of-7 for 52 yards in his one quarter.
The Giants got a safety later in the period after two more Cleveland penalties pushed the Browns back to their own 1.
Zastudil, with only 10 yards to punt, deflected his kick off teammate Travis Thomas out of bounds for a safety. Hixon returned the ensuing free kick 82 yards for his third TD.
Cleveland's Syndric Steptoe returned the kickoff 90 yards to the Giants' 9 on the last play of the first quarter. Two plays later, Derek Anderson and Jamal Lewis botched a handoff and New York's James Butler returned it 95 yards for the touchdown that made it 30-3.
Anderson, who was 4-of-10 for 20 yards under pressure from the Giants defense, left the game shortly after with a possible concussion after being sacked by Osi Umenyiora.
It was 30-17 at halftime after Steptoe ran 7 yards for a score and two of the mistake makers, Adams and Eric Wright, combined for a Cleveland touchdown - Adams slamming into Giants QB Anthony Wright as he attempted to pass. Eric Wright grabbed it and took it in from 15 yards.
Brady Quinn, who was 7-of-12 for 124 yards, hit Steptoe for a 44-yard TD pass on the first series of the second half to cut it to 30-24. But Ahmad Bradshaw went in from a yard out on the next drive to make it a two-score lead again.
Jason Reda's 44-yard field goal with 7:07 left in the game made it 37-27. And Ken Dorsey's 8-yard touchdown pass to Lance Leggett with 2:25 left cut it to 37-34.
