Interviewed on CBS's "The Early Show," she was asked what she thought about Republican Sarah Palin's vice presidential candidacy.
She said she thought any woman is going to face certain issues and questions but that "the bottom line is who is on top of the ticket."
Clinton called Republican presidential nominee John McCain a friend, but said that he has a record of supporting deregulation of business.
"Barack Obama's going to win. No doubt ... if anybody looks at the mess we're in today," she said.
She also said that she thinks Obama is best suited to straighten out the country's economic problems.
"Barack Obama is being advised by the same people who got us out of the ditch in 1993," she said. "I think our ticket is well-equipped for handling the mess that they're going to inherit.
Let's make no mistake about it: this is going to be one of the most difficult presidential transitions."