The two local Pakistani intelligence officials said the strike occurred Thursday in Tappi village in North Waziristan, a region considered a stronghold for al-Qaida and Taliban militants.
The officials requested anonymity because they were not authorized to speak to media.
The U.S. is suspected in a surge of recent missile strikes in Pakistani territory. Pakistan, a U.S. ally in the war on terror, has protested such strikes as violations of its sovereignty.