The show will include many of pop's top female singers. Also part of the performing lineup: Christina Aguilera, Mariah Carey, Alicia Keys, Taylor Swift and Rihanna.
Annie Lennox is to receive the AMA's Award of Merit.
Jimmy Kimmel is set to host the 36th annual event. Other performers include Kanye West, the Jonas Brothers, Ne-Yo and Miley Cyrus.