Israeli officials would not comment Wednesday, pending an announcement from the Vatican. No dates were given.
A Vatican delegation met with Israeli President Shimon Peres last week to discuss a possible visit.
The late Pope John Paul II came to the Holy Land in a 2000 pilgrimage, visiting Israel and the Palestinian territories.
That was the first official visit by a pope to Israel.
The Vatican and Israel established diplomatic ties in 1994 after hundreds of years of painful relations between Catholicism and Judaism.