The only senators who voted against Holder in committee were Republicans John Cornyn of Texas and Tom Coburn of Oklahoma.
Cornyn criticized Holder's role in controversial pardons and questioned whether he would protect intelligence agents who participated in harsh interrogations.
Holder's supporters said he wouldn't be afraid to tell President Barack Obama he was wrong. They praised him for declaring that waterboarding as an interrogation technique is torture. And they said he would be tough on crime.
"When asked whether this country at is at war he said yes," said Sen. Lindsey Graham, R-S.C. "He indicated the enemy have declared war on this country long before we realized it. He sees the battlefield as the entire globe."
Graham said he supports Holder's view that the country needs to interrogate terrorism suspects in accordance with American values.
"I am confident this new attorney general will have a balanced approach and I look forward to working with him. I know he's made mistakes and so have I," Graham said.
Several senators praised Holder for his willingness to admit his mistake, when he told the White House he was leaning in favor of Bill Clinton's pardon of fugitive financier Marc Rich - whose wife was a major Democratic contributor.
Sen. Jeff Sessions, R-Ala. said Holder has "extraordinary experience" as a former judge, deputy attorney general and U.S.
attorney for the District of Columbia.
"He made some big mistakes when he should have really dug his heels in," Sessions said. "He indicated he understands that error."
Sen. Charles Schumer, D-N.Y. said that with Holder as attorney general, "Waterboarding is history. Guantanamo Bay is history."
Referring to the politics that ran rampant through the Bush Justice Department, Schumer added, "The rancid (political) considerations of the Department of Justice will be history."