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Heavy flames and smoke tore through the two-story structure, sending debris flying.
Neighbors say there was an explosion before the fire ripped through the second floor apartment.
After firefighters put out the flames, they discovered two bodies.
People say the couple who was found dead, was quiet. They drove to work every morning to the nail salon that they owned on Long Island.
One victim was found in the living room, the other was found in the bedroom.
Firefighters also had to rescue an elderly neighbor.
"It does not appear there was a smoke detector in the apartment at the time, but it's difficult to make that determination also, because of the large amount of fire," said Deputy Asst. Chief John Sudnik.
As firefighters searched the structure, residents stood outside in the cold.
Fire department spokesman Jim Long said the fire - which was brought under control in less than an hour - was considered suspicious and fire marshals were investigating the cause.
The victims' ages and their relationship were not immediately known. Their bodies were found in different parts of the apartment, Sudnik said.
Four firefighters suffered minor injuries.
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