"We're going to attempt to conduct a full interview exclusively on Twitter - complete with the 140-character limit," Stephanopoulos said in a statement Friday. He said it was the latest in an effort to find new ways to connect with viewers of "This Week," which he anchors.
The public will be able to read the real-time 15-minute exchange by signing up at the Twitter site to follow both Stephanopoulos and McCain.
Meanwhile, Stephanopoulos is inviting everyone to "tweet" him proposed questions - with a 140-character limit.
Twitter is a growing Internet phenomenon, with millions of participants, including increasing numbers of public figures who use it to reach their supporters.
While messages posted by the average Twitter user might be read by a few dozen registered "followers," Stephanopoulos' Twitter page Friday listed more than 148,000 followers, while McCain could claim nearly 200,000.
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