The Mets celebrated and the runners resumed their trip around the bases.
Pedro Feliciano (1-1) pitched the eighth. J.J. Putz pitched the ninth for his second save, getting some fielding help from third baseman David Wright on a hard grounder down the line with a runner on first. Shortstop Ramon Martinez, who made two errors on Friday night, stabbed Mike Lowell's hard grounder in the hole for the final out.
Papelbon (0-1) had been 11 for 11 in save opportunities. But Gary Sheffield walked to lead off the ninth and then, after Papelbon struck out Wright and Jeremy Reed, Santos hit the first pitch for his second career homer.
The late drama deprived Josh Beckett of a victory after his longest outing of the season, in which he followed an unearned run in the first with seven scoreless innings. The Red Sox took a 2-1 lead on Kevin Youkilis' two-run single in the first, but they didn't score again off Mike Pelfrey, who left after seven.
Struggling slugger David Ortiz, who hit his first home run of the season on Wednesday night, went 0 for 3 while stranding four baserunners to see his batting average drop to .201.
Beckett had more trouble with his fielding than his pitching.
With Sheffield at the plate in the first, he threw the ball away for an error trying to pick Carlos Beltran off first base, allowing him to move to second. Beckett then chased Sheffield's popup into foul territory but pulled off at the last second as third-baseman Mike Lowell slid in.
The ball dropped, Sheffield stayed at the plate and then on the next pitch singled in Beltran to make it 1-0.
Boston took the lead when Jacoby Ellsbury and Dustin Pedroia singled to lead off the first, then moved up on a double-steal. After Ortiz struck out, Youkilis singled to left to make it 2-1.
Both pitchers coasted until the Mets put runners on first and third with one out in the seventh. Beckett struck out Ramon Martinez and Luis Castillo lined out to center to end the threat.
Notes: Boston 1B/OF Mark Kotsay played six innings in Pawtucket on a rehab assignment while recovering from back surgery and went 1 for 3. ... Red Sox SS Julio Lugo got the day off with a day game on Sunday. ... The Mets sat OF Ryan Church, who left Friday night's game with a sore hamstring, and Jose Reyes, who is day-to-day with a tendinitis in his right calf. Carlos (sore right knee) was the designated hitter for the second straight game. ... Ellsbury has hit in 18 straight games, the longest for a Boston OF since Johnny Damon hit in 29 in a row in 2005.
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