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That brings the number of New York City deaths related to swine flu to seven.
Six of the seven deaths have occurred in people with other health problems, presumably including at least one of the new deaths. One case is still being investigated.
Health officials say an adult in Onondaga County is the first person outside New York City to die of swine flu.
Onondaga County Health Commissioner Dr. Cynthia Morrow says the resident had underlying medical conditions.
She says officials aren't identifying the patient at the family's request and to protect their privacy. The person died recently in a hospital and the state confirmed the death Tuesday night.
To date, Onondaga County has had 42 confirmed cases of H1N1, including three hospitalizations. The flu has stricken students in Syracuse and five other neighboring school districts.
State officials reported 780 confirmed cases of the H1N1 virus as of Tuesday.
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