Eyewitness News is told at least two residents were being treated for injuries.
Fire shot out the windows of several apartments on the ninth floor, and heavy smoke was reported through the building.
Officials say firefighters set up a command post in the lobby of the building, which was not evacuated.
Second Avenue was closed for fire department activity.
MORE NEW YORK AND TRI-STATE AREA NEWS
SEND TIP OR PHOTO || REPORT TYPO || GET WIDGET
EYEWITNESS TWITTER || FIND US ON FACEBOOK