Eyewitness News has learned the fire erupted in a commercial building on 27th Street just before 6 a.m.
Heavy smoke spewed from the fire and across the inbound lanes of the nearby elevated Long Island Expressway.
The Long Island Expressway's inbound lanes were temporarily closed as firefighters battled the flames.
The lanes were shortly reopened afterward, but big delays still remain as drivers approach the Queens Midtown Tunnel.
No injuries were immediately reported.
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