Heavy flames shot through the roof of several of the businesses.
The blaze originated in the basement of the American Diner, which was closed at the time. It then spread to the supermarket next door.
The Fire Marshall's office is looking into the cause.
"Right now it's under investigation by the bureau of fire investigation due to the amount of fire that was here on arrival," said Asst. Chief Edward Baggot.
This fire is devastating because the neighborhood suffered another fire recently on Halloween day when it destroyed 10 businesses.
Residents are suspicious. "The first time it was the bakery and now again, it doesn't make sense," said Carolyn Emmanuel.
Two firefighter sustained minor injuries battling the blaze.