DEA Special Agent-In-Charge John Gilbride says the handout is "very disturbing."
The city's Department of Health and Mental Hygiene printed about 70,000 copies of the handout.
A health official says the goal is to promote health and save lives.
Assistant Commissioner Daliah Heller says instructions on how to perform injections were included because there is "a less harmful way to inject."
The illustrated guidebook offers information on HIV testing and the dangers of sharing needles.