Firefighters fought through heavy smoke and flame to pull residents from a second-floor apartment.
Eyewitness News is told three residents were pulled from the building, all with life-threatening injuries.
Officials say a 35-year-old man was pronounced dead at Interfaith Medical Center. An 81-year-old man and 40-year-old woman were also hospitalized in critical condition.
A 14-year-old boy was being questioned by investigators looking into the fire, which they said appeared suspicious.
The boy reportedly told them he saw an unknown person run out of a second-floor apartment at the time of the fire. Investigators were looking into his story.
Fire marshals are investigating the cause of the blaze.