Detectives say a bullet hit 5-year-old Syniah Herndon in the leg.
The girl was accidentally struck while the suspect fired at two other men.
The little girl was taken to Kings County Hospital for her injury.
The other two men were treated for gunshot wounds to their arms.
Police say the suspects fled in a grey Nissan westbound on Halsey Street.
Anyone with information about the shooting is asked to call Crime Stoppers at 800-577-TIPS (8477).