Turnpike Authority spokesman Joe Orlando says there's a six-mile backup heading north near Hamilton because one truck remains in the right lane.
Orlando says workers have been unloading the truck and plans call for towing it. However, the wreck may not be cleared until at least 8:30 a.m.
Orlando says the accident may have occured when one driver suffered an unknown health problem around 12:30 a.m. Thursday.
Orlando says he's in serious condition.
The other trucks were moved off the toll road.
The accident remains under investigation.