The accident occurred at about 1:30 p.m. Wednesday just south of Interchange 13A.
Two tractor-trailers, a dump truck, a box truck, a pickup truck and three cars were involved. Authorities said the driver of the pickup truck was killed. The victim's name has not been released.
Turnpike Authority spokesman Joe Orlando said the southbound lanes of the turnpike's outer roadway were closed until 7:30 p.m. as state police investigated and the wreckage was cleared.
Orlando said the crash backed up southbound traffic for 12 miles.