It happened on the Major Deegan Expressway at Fordham Road at 3:47 a.m. Saturday.
Police say Pablo Ovalles, 26, of Roslindale, Massachusetts, was driving his Cadillac Escalade northbound in the southbound lane and smashed into an Infiniti.
Police say the driver of the Infiniti, Patrick Smith, 42, of Hackensack, New Jersey, was pronounced dead at St. Barnabas Hospital.
Ovalles was rushed to Lincoln Hospital in stable condition.
Police later arrested Ovalles for DWI and vehicular manslaughter.