It happened at Nassau Road at Exit 21 around 5 a.m.
The 2006 Saturn Ion went off the roadway, struck a bridge embankment and caught fire.
An uninvolved motorist and good samaritan stopped and helped a State Trooper to free the passenger from the backseat.
The vehicle became fully engulfed in flames with the driver and front seat passenger trapped inside.
The driver, Brendon McRae, 24, of Roosevelt, and Stanley Sagesse, 23, of Hempstead, were pronounced dead at the scene.
The backseat passenger, Naquan Bell, 21, of Floral Park, was rushed to Nassau University Medical Center where he later died.
Two of the victims worked at Winthrop University Hospital.
The hospital released this statement:
"The news about the tragic accident this morning was devastating to the staff of Winthrop University Hospital. The Winthrop team works very closely and is much like a large family. The heartfelt condolences of our administration, medical and nursing staff and Friends and colleagues of Brendon McRae and Stanley Sagesse along with our prayers are extended to Brendan and Stanley's families."
We spoke to mister Sagesse's father on Sunday. He said the family is devastated and asked for privacy.