The woman is 40-year-old Tina Adovasio of Edison Avenue in the Bronx.
She is described 5'05" tall, 135 pounds with a slim build.
She was last seen wearing a black jacket, blue jeans and a pair of "UGG" boots.
Adovasio was last seen at her home around 9:00 Friday night.
Police say Adovasio and her husband have a history of domestic violence.
Detectives are questioning the husband, who they say has physically hurt Adovasio in the past.
Anyone with information in regards to the above missing is asked to call Crime Stoppers at 1 800 577 TIPS (8477). You can also submit tips by logging onto the Crime Stoppers website at www.nypdcrimestoppers.com or by texting tips to 274637 (CRIMES) then enter TIP577.