It happened early Saturday morning in front of a building on East 138th Street in the Mott Haven section.
Police say they responded to a report of an assault and found Quentin Guerro, 61, unconscious with a head injury.
Guerro was later pronounced dead at the hospital.
Kendall Major, 35, and Tosheba Alford, 20, both from Queens were arrested at the scene.
Major and Alfred are charged with murder.