It happened just after 5 p.m. at the intersection of East County Line and Monmouth Avenue.
A car was crushed beyond recognition when it collided with a school bus.
The bus flipped on its side and it pinned the leg of a 16-year-old bicyclist.
A passenger inside of the Honda and the teenage girl are in critical condition.
There were no children aboard the bus at the time of the accident.
Both drivers were treated and released from Kimball Medical Center. Blood tests were done on both to measure their blood alcohol level.
No determination on criminality has been made, and the accident is under investigation.