Police say the accident happened around 3 p.m. at the intersection of Scotland Road and Maryland Street.
The SUV was flipped over when Newscopter 7 arrived on the scene.
There were two people injured in the SUV. They were literally cut out of the SUV and taken to University Hospital in stable condition.
There were 14 passengers on the bus at the time of the accident. The injuries on the bus were minor.
The bus is owned by Coach USA and makes local stops in Orange and in Newark.