The bill makes it a crime to possess or sell the chemicals used to make the drugs.
Marketed as bath salts or incense, they're snorted by users and mimic the effects of cocaine and methamphetamines. They can cause health issues ranging from increased blood pressure and heart rate to hallucinations and suicidal thoughts.
The bill must also pass the Assembly and be signed by the governor before becoming law.
In April, New Jersey's attorney general classified the chemicals used to make the drug as controlled dangerous substances.
A law passed by the Kansas Legislature to ban bath salts took effect on Saturday.