Police say a car pulled up to a group of people outside a building in the South Ward and opened fire at about 10 p.m. Monday.
A 15-year-old boy, identified as Aziz Stewart, was killed and eight others were hurt. Authorities say the victims, five males and three females, ranged in age from 12 to 32.
About four hours earlier, three men and a woman were wounded in a shooting downtown.
Another woman was shot in the city's Central Ward.
No arrests have been made.