The victim, Gloria Nartey, was shot in the back of the head just steps from her home around 9:30 Monday night.
Emergency crews performed CPR on the victim but were unable to revive her. She was pronounced dead at Mt. Vernon Hospital.
Police say Nartey was an innocent bystander walking home after doing some grocery shopping.
She was hit when the gunman opened fire on two men on the block.
The suspect then cut through a backyard.
A 25-year-old man, possibly the intended target, was also shot and injured.
As detectives investigate and search for the suspect, uniformed officers patrolled South 12th Avenue, where residents say the sound of gunfire, and even death has become all too common.