Holly is her mom's little princess, but this girl's fairytale started with a scare. While pregnant with holly, Vicki Davis found out she was a carrier of Fragile X syndrome.
"I had never heard of it. I had no clue what it was," she said.
It's a mutation of a gene on the X chromosome that leads to lack of protein production, critical for development. It is one of the most common causes of mental retardation and autism.
"Thirty percent of individuals with Fragile X syndrome have full autism. Another 30 percent have an autism spectrum disorder," said Randi Hagerman, medical director of the MIND Institute and professor of pediatrics at the UC Davis Medical Center.
Hagerman says she first met Holly when she was just a few months old. The infant's Fragile X syndrome was subtle, but "she was extremely delayed," said Hagerman.
As part of a clinical trial, Holly started taking a serotonin medication. Then, minocycline, a common antibiotic normally used to treat acne, was added to her regimen.
"Her developmental testing just improved remarkably," said Hagerman.
Holly didn't start talking until she was two and a half. Vicki says additional minocycline treatments around that time helped her catch up to other kids and even excel. At just four she started reading.
"The medication really helped her create some of those pathways that taught her how to learn," said Davis.
Hagerman hopes the treatments that helped Holly could do the same for autistic kids, and that could mean a lot most children living happily ever after.
Hagerman says the drugs Holly was treated with have a few side effects like some gastro-intestinal issues, and rare severe headaches. She says the drug treatment can be used in older kids with Fragile X, however the results might not be as dramatic. The MIND institute is currently testing other investigational drugs to improve core symptoms of Fragile X syndrome for five to 25 year olds.
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