"666" was scrawled on the front of Chaminade High School located at 340 Jackson Avenue in Mineola.
A motorcycle shop and several cars were also tagged.
Police say a swastika and other hate graffiti were visible in many locations.
The word "arian" was spray painted on a sidewalk in front of the school.
Crews quickly cleaned up the graffiti at the high school.
So far no arrests as police investigate.
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