Police said the incident happened around 5 a.m.
The bus had been traveling along 50th Street when it was hit by the Mercedes going north on Sixth Avenue, in the vicinity of Radio City Music Hall.
Police said the bus driver and the four passengers were taken to area hospitals with non-life threatening injuries, including a fractured skull and neck and back injuries.
The driver of the Mercedes was taken into custody on suspicion of driving while intoxicated.
Witnesses said the Mercedes may have been drag racing and police say the vehicle ran a red light before colliding with the van.
CLICK HERE TO SEE MORE PHOTOS FROM THE ACCIDENT http://abclocal.go.com/wabc/gallery?section=news&id=8812515&photo=1
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