The man, who was arrested and taken to an area hospital, pointed a gun at police, according to a statement from the Chicago Police Department's Office of News Affairs.
An officer then shot the offender, according to police. No officers were injured.
Police were responding to a call of shots fired around 6700 S. Morgan when a chase by car and then by foot ensued, police said.
Two other people were arrested. The weapon was recovered on the scene.
