The American Airlines flight was bound for the Dominican Republic on November 12, 2001 when it crashed in Belle Harbor after taking off from John F. Kennedy International Airport.
All 260 on board were killed, as well as five people on the ground.
Many of the passengers were Dominican.
The disaster jarred a city still raw and fearful just two months after the terrorist attacks on the World Trade Center.
New York City Mayor Michael Bloomberg spake at the memorial service at the Holy Spirit Catholic Church, which is home to one of the city's largest Dominican congregations.
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