Ophadell Williams faces more than 50 criminal charges, including manslaughter and criminally negligent homicide.
In March of 2011, the bus he was driving struck a guard rail, toppled over and hit a signpost that ripped open the top of the bus.
Prosecutors argued that Williams knew the risks of fatigue and drove anyway despite a serious lack of sleep.
If convicted, he faces a maximum of 7 1/2 years to 15 years in prison.
The National Transportation Safety Board said in June that the accident was probably caused by driver fatigue, and a bus company that provided too little safety oversight. It stopped short of saying Williams had fallen asleep.
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