The fire broke out inside Portuguese Auto Repair on 7th Street just before 4:30 a.m.
The flames burned through numerous vehicles in the auto body shop.
Numerous loud explosions inside the business were believed caused by gas or propane tanks.
Crews initially had to force their way into the business to gain access.
No injuries were immediately reported.
Meanwhile, a three-alarm fire burned through a home at 315 Broad Street in Keyport. Residents escaped the fire, which appears to have started in the attic at around 4:15 a.m.
Several houses were also reported on fire on Mystic Island in Little Egg Harbor, Ocean County.
Get Eyewitness News Delivered