The flames broke out at the Spice and Curry restaurant on Hempstead Turnpike in East Meadow just before 10:30 p.m. and quickly spread to two other businesses - We Buy Gold and Wine and Spirits.
All the buildings sustained substantial damage.
Seventy-five firefighters battled the blaze, which at this time is being deemed accidental.
No injuries were reported.
CLICK HERE to see images from the scene.
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