The accident happened just after 1 a.m. on the Long Island Expressway Service Road in Medford.
Police say the car crossed over North Ocean Avenue and went airborne, eventually crashing into two trees.
The car split into pieces, and the driver was thrown from the vehicle.
The driver was pronounced dead at the scene of the crash.
A search was done of the area for any other victims that may have been in the car, and no other bodies were found.