The one-car crash happened just before 1:30 a.m. on Irvine Turner Boulevard, where a Dodge Neon struck a tree.
All 10 passengers were injured and trapped inside the vehicle.
The eight children in the car were between the ages of 1½ to 17 years old.
Three of the children are in critical condition
A 31-year-old man is in stable condition and a 30-year-old female is hospitalized as well. Her condition is not yet known.
Police are trying to determine the relationship between the unmarried couple and the eight children.
Investigators have not determined the cause or contributing factors to the accident, and no charges have been filed at this time.