The shooting happened on North Munn Avenue in the city's west ward around 11:30 p.m.
One person, 29-year-old Laqueebah Murray, died from a gunshot to the head, while another was struck in the arm and a third grazed in the leg.
So far, no arrests have been made.
Police searched an apartment building and a large area surrounding it, looking for a suspect.
Police set up a command post at Tremont and North Munn avenues as they investigated.
