Police say a 33-year old motorcycle rider was heading eastbound on Queens Boulevard at about 4 a.m. when he hit the pedestrian, who was attempting to cross the street northbound on 44th Street.
The victim, a 50-year old man, was pronounced dead at the scene.
His identity has not yet been released.
The motorcycle driver was taken to Elmhurst Hospital, where he is listed in critical condition.
The accident is under investigation.