The accident happened at around 8:40 p.m. at the intersection of Bedford and Clarkson Avenues in Prospect-Lefferts Gardens.
The Mercedes Benz struck the woman who was on the sidewalk and then hit the NSA Supermarkets store.
The woman was taken to Kings County Hospital in serious condition. She had been waiting for a bus in front of the store at the time of the crash.
The accident is under investigation.