A Correction Department spokesman says the fracas at the George Vierno Center started late Friday night.
It was not immediately clear how the fight started.
Four correction officers were treated for exposure to an unknown chemical agent.
Several inmates also suffered minor injuries.
The spokesman says that officers responded within minutes. The incident is under investigation.
Rikers Island is located in the waters of Long Island Sound near LaGuardia Airport. It is the city's primary jail.
It predominantly holds inmates awaiting trial or serving sentences of less than a year. It currently holds approximately 12,000 inmates.