The shooting took place at about 11:30 a.m. on the 400 block of Springfield Avenue in the West Ward.
Shots were fired at a car, hitting at least three people inside.
City Police Director Samuel DeMaio told (The Star-Ledger) that the car's driver, Akbar Muhammad, and a female passenger were killed in the shooting.
The three other victims were all hospitalized in stable condition.
The Newark Police Department and the Essex County Prosecutor's Office Homicide/Major Crimes Task Force are investigating the shooting.
Anyone with information is asked to contact the Essex County Prosecutor's Office Homicide/Major Crimes Task Force tips hotline at 1-877-847-7432.