The incident happened just before 1 p.m. on Cumberland Place in Valley Stream.
Authorities say the suspects pushed their way inside the home and forced a 53-year-old man and his 21-year-old daughter onto the floor.
After robbing and ransacking the house, they handcuffed the victims to an oil tank in the basement.
The first suspect is described as being 5-foot-11 and weighing 230 pounds. He was wearing a mask and armed with a semi-automatic hand gun.
The second suspect was also about 5-foot-11 but weighed around 170 pounds.
They stole assorted items, including cash and jewelry from the home, before fleeing in an unknown direction.
There were no injuries reported.
Detectives request anyone with information regarding the above crime to contact Nassau County Crime Stoppers at 1-800-244-TIPS. All callers will remain anonymous.