The incident happened on just after 10 a.m. on Saturday, March 1, at the HealthSource drug store on Second Avenue on the Upper East Side.
The suspect entered the store armed with a gun and demanded Oxycodone, Viagra and Cialis pills.
The clerk complied, and the man fled the scene.
There were no reported injuries.
The suspect is described as a dark-skinned Hispanic male, about 6-feet tall and weighing roughly 190 pounds.
Anyone with information in regards to this incident is asked to call Crime stoppers at 1-800-577-TIPS (8477).