The sequel features Andrew Garfield reprising his role as Peter Parker and his comic book alter-ego, the Amazing Spider-Man. It made history as the first movie to feature the character to be shot entirely in New York.
"You could feel the atmosphere of the city, which is so important to the Spider-Man story because he is the most New York superhero I can imagine," said co-star Emma Stone, who plays Gwen Stacy.
Peter Parker is just a nerdy kid from Queens, which Garfield took to heart.
"Before the first movie, I went and hung out for a couple of weeks in Queens with a bunch of high school kids and tried to pick up exactly what sounds they were making," he said. "And I tried to incorporate that into who Peter was, because he has to be from Queens."
It's easier said than done for an actor raised in Britain.
"God goes to 'gahd,' so you open up, you gotta place the accent forward," he said. "you've got hit the R's much more as well."
And speaking of hitting, most Spider-Man fans don't come for the conversation. As Electro, Jaime Foxx is almost unrecognizable. But devoted fans still approached him in Times Square.
"Peoples running up to me like 'Yo, Foxx, I got this mix tape, man. You take my mix tape? CD? Yeah, I see you with the blue stuff on, here. Hit me up,'" he said. "So that also makes it cool. That's the real New York."
Cast and crew were only in the real Times Square for a couple of nights.
"It was kind of guerilla-style filmmaking, because you can't close Tines Square," director Marc Webb said. "So we just jumped out of a van and shot Jaime Foxx for a couple of minutes, and then we built an entire version of Times Square out on Long Island."
"The Amazing Spider-Man 2" begins with a high-speed chase that left more than 80 police cars destroyed, but that could not be shot here due to the city's 30-miles per hour speed limit. So stunt drivers took to the streets of Rochester, where city officials allowed them to go as fast they liked.
The movie is from Columbia Pictures and Marvel Entertainment, which is owned by the same parent company WABC-TV.