Over a show-business career that lasted for more than 40 years, Shandling won acclaim as a sitcom writer, standup comedian, actor and producer.
But he won the most critical acclaim of his career for "The Larry Sanders Show" on HBO, which aired from 1992 to 1998. In it, he played the titular talk show host, in some ways a comic alter ego of his own neurotic persona. The show was nominated for 56 Emmys, winning three, and placed high on many critics' lists of the best TV shows of all time.
Shandling also appeared in numerous movies, including "Zoolander," "Captain America: The Winter Soldier" and "Iron Man 2." He hosted the Emmy and Grammy award shows multiple times.
Other comedians have taken to social media to post about Shandling's death:
Goodbye Gary Shandling thank you for your kindness and your generosity and for making me laugh so damn much— Amy Schumer (@amyschumer) March 24, 2016
Sunday, my longtime friend Garry Shandling was here, making every1 laugh. I loved him. I'll miss our talks the most. pic.twitter.com/Ud8AQXNBXN— Kathy Griffin (@kathygriffin) March 24, 2016