The accident happened at about 10:47 Saturday night on Pine Aire Drive in North Bay Shore.
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Suffolk County Police say 63-year-old James Antonelli was riding a 2008 Harley Davidson motorcycle when he was struck by a vehicle that drove out of a 7-Eleven parking lot.
Antonelli was thrown into the westbound lane where he was struck by a 2004 Mercury sedan.
That vehicle was driven by a 54-year-old Bay Shore woman who stopped and stayed at the scene.
But police say the first vehicle fled westbound on Pine Aire Boulevard. It is described as a black four-door sedan.
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Antonelli, of Bay Shore, was taken to Southside Hospital with serious injuries.
The vehicles were impounded for safety checks.
Detectives are asking anyone with information to call the Third Squad at 631-854-8352 or anonymously to Crime Stoppers at 1-800-220-TIPS.
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